ADP-ribosylhydrolase 1

(ADP-ribosyl)hydrolase 1, also termed [Protein ADP-ribosylarginine] hydrolase and protein-N^ω-(ADP-D-ribosyl)-L-arginine ADP-ribosylhydrolase (EC 3.2.2.19), is an enzyme that in humans is encoded by the ADPRH gene.^{[1][2][3][4][5]} This enzyme is a specific mono(ADP-ribosyl)hydrolase that catalyses the removal of an ADP-ribosyl modification from target arginine residues of protein substrates.^[4][6] The chemical reactions can formally be described as follows:

N^ω-(ADP-D-ribosyl)-L-arginyl-[protein] + H₂O ${\displaystyle \rightleftharpoons }$ ADP-D-ribose + L-arginyl-[protein]

In addition, the enzyme can reverse the ADP-ribosylation of free arginine:^[6][7][8]

N^ω-(ADP-D-ribosyl)-L-arginine + H₂O ${\displaystyle \rightleftharpoons }$ ADP-D-ribose + L-arginine

ADP-ribosylhydrolase 1
Structure of human (ADP-ribosyl)hydrolase ARH1 in complex with ADP-ribose (PDB 6G28).
Identifiers
EC no.	3.2.2.19
CAS no.	98668-52-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

See also

• ADP-ribosylhydrolase