TRNA (carboxymethyluridine34-5-O)-methyltransferase

TRNA (carboxymethyluridine³⁴-5-O)-methyltransferase (EC 2.1.1.229, ALKBH8, ABH8, Trm9, tRNA methyltransferase 9) is an enzyme with systematic name S-adenosyl-L-methionine:tRNA (carboxymethyluridine³⁴-5-O)-methyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + carboxymethyluridine³⁴ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 5-(2-methoxy-2-oxoethyl)uridine³⁴ in tRNA

TRNA (carboxymethyluridine34-5-O)-methyltransferase
Identifiers
EC no.	2.1.1.229
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The enzyme catalyses the posttranslational modification of uridine residues at the wobble position 34 of the anticodon loop of tRNA.