ASCC3

Activating signal cointegrator 1 complex subunit 3 is a protein that in humans is encoded by the ASCC3 gene.^[5][6]

ASCC3
Identifiers
Aliases	ASCC3, ASC1p200, HELIC1, RNAH, activating signal cointegrator 1 complex subunit 3
External IDs	OMIM: 614217; MGI: 1925237; HomoloGene: 4973; GeneCards: ASCC3; OMA:ASCC3 - orthologs
Gene location (Human) Chr. Chromosome 6 (human)[1] Band 6q16.3 Start 100,508,194 bp[1] End 100,881,372 bp[1]
Gene location (Mouse) Chr. Chromosome 10 (mouse)[2] Band 10|10 B3 Start 50,468,765 bp[2] End 50,727,581 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in decidua secondary oocyte Achilles tendon gonad stromal cell of endometrium ventricular zone testicle islet of Langerhans bone marrow cells right coronary artery Top expressed in spermatid tail of embryo gastrula spermatocyte genital tubercle epithelium of small intestine supraoptic nucleus hand ascending aorta submandibular gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function nucleotide binding 3'-5' DNA helicase activity protein binding hydrolase activity ATP binding helicase activity nucleic acid binding RNA binding Cellular component intracellular anatomical structure membrane nucleoplasm nucleus cytosol activating signal cointegrator 1 complex nuclear speck cytoplasm Golgi apparatus Biological process DNA dealkylation involved in DNA repair DNA duplex unwinding cell population proliferation regulation of transcription, DNA-templated transcription, DNA-templated cellular response to DNA damage stimulus DNA repair Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 10973 77987 Ensembl ENSG00000112249 ENSMUSG00000038774 UniProt Q8N3C0 E9PZJ8 RefSeq (mRNA) NM_001284271 NM_006828 NM_022091 NM_198007 RefSeq (protein) NP_001271200 NP_006819 NP_071374 NP_932124 Location (UCSC) Chr 6: 100.51 – 100.88 Mb Chr 10: 50.47 – 50.73 Mb PubMed search [3] [4]
Wikidata
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Interactions

ASCC3 has been shown to interact with RELA,^[7] C-jun^[7] and Serum response factor.^[7]