ATF/CREB

The ATF/CREB family is a group of transcription factors, consisting of different ATFs (Activating transcription factors), CREB (cAMP response element binding protein), CREM (cAMP response element modulator) and related proteins.^[1][2] Among the transcription factors assigned to this group, some are more related to CREB-like, factors, whereas other exhibit closer similarity with the AP-1 transcription factor components c-Jun or c-Fos.^[3]

Common features are a basic leucine zipper type of DNA-binding domain and binding as a dimer to DNA sequences like 5'-TGACGTCA-3' or 5'-TGA(C/G)TCA-3' as recognition sequences.^[4]