ATP-dependent NAD(P)H-hydrate dehydratase

The enzyme ATP-dependent NAD(P)H-hydrate dehydratase (EC 4.2.1.93) catalyzes the chemical reactions

ATP + (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide ${\displaystyle \rightleftharpoons }$ ADP + phosphate + NADH

ATP + (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine dinucleotide phosphate ${\displaystyle \rightleftharpoons }$ ADP + phosphate + NADPH

ATP-dependent NAD(P)H-hydrate dehydratase
Identifiers
EC no.	4.2.1.93
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (6S)-6-β-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-dinucleotide hydro-lyase (ATP-hydrolysing; NADH-forming). Other names in common use include reduced nicotinamide adenine dinucleotide hydrate dehydratase, ATP-dependent H4NAD(P)+OH dehydratase, (6S)-β-6-hydroxy-1,4,5,6-tetrahydronicotinamide-adenine-, and dinucleotide hydro-lyase (ATP-hydrolysing).