Acetate CoA-transferase

In enzymology, an acetate CoA-transferase (EC 2.8.3.8) is an enzyme that catalyzes the chemical reaction

acyl-CoA + acetate ${\displaystyle \rightleftharpoons }$ a fatty acid anion + acetyl-CoA

acetate CoA-transferase
Identifiers
EC no.	2.8.3.8
CAS no.	37278-35-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are acyl-CoA and acetate, whereas its two products are long-chain carboxylate anion and acetyl-CoA.

This enzyme belongs to the family of transferases, specifically the CoA-transferases. The systematic name of this enzyme class is acyl-CoA:acetate CoA-transferase. Other names in common use include acetate coenzyme A-transferase, butyryl CoA:acetate CoA transferase, butyryl coenzyme A transferase, and succinyl-CoA:acetate CoA transferase.

This enzyme participates in 4 metabolic pathways:

• benzoate metabolism via ligation of CoA
• propanoate metabolism
• butanoate metabolism
• two-component system.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1K6D.