Adenosine 5'-tetraphosphate

Adenosine 5′-tetraphosphate, Ap4 or ATPP is a nucleotide. It is produced from ATP and triphosphate (P₃) through the action of acetyl—CoA synthetase.^[1] Acetyl—CoA synthetase also produces adenosine 5'-pentaphosphate through the reaction of ADP and tetraphosphate (P₄).

Adenosine 5'-tetraphosphate

Names
IUPAC name Adenosine 5′-(pentahydrogen tetraphosphate)
Systematic IUPAC name O1-{{#parsoidfragment:0}}{[(2R,3S,4R,5R)-5-(6-Amino-9H-purin-9-yl)-3,4-dihydroxyoxolan-2-yl]methyl} pentahydrogen tetraphosphate
Other names Adenosine tetraphosphate
Identifiers
CAS Number	1062-98-2 N
3D model (JSmol)	Interactive image
ChEBI	CHEBI:18334
ChEMBL	ChEMBL490984
ChemSpider	13390
KEGG	C03483
PubChem CID	14003
UNII	DBK98M4ZT7 Y
CompTox Dashboard (EPA)	DTXSID901261206
InChI InChI=1S/C10H17N5O16P4/c11-8-5-9(13-2-12-8)15(3-14-5)10-7(17)6(16)4(28-10)1-27-33(21,22)30-35(25,26)31-34(23,24)29-32(18,19)20/h2-4,6-7,10,16-17H,1H2,(H,21,22)(H,23,24)(H,25,26)(H2,11,12,13)(H2,18,19,20)/t4-,6-,7-,10-/m1/s1 Key: WWMWAMFHUSTZTA-KQYNXXCUSA-N
SMILES Nc1ncnc2n(cnc12)[C@@H]1O[C@H](COP(O)(=O)OP(O)(=O)OP(O)(=O)OP(O)(O)=O)[C@@H](O)[C@H]1O
Properties
Chemical formula	C10H17N5O16P4
Molar mass	587.160 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Functions

ATPP has been found to play physiological roles in some mammals.

Rabbits

ATPP is a constituent of aqueous humor in rabbits, where it was found to reduce the intraocular pressure.^[2]

Rats

ATPP has been suggested to play a regulatory role in rat aorta.