Adenosylmethionine hydrolase

In enzymology, an adenosylmethionine hydrolase (EC 3.3.1.2) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + H₂O ${\displaystyle \rightleftharpoons }$ L-homoserine + methylthioadenosine

adenosylmethionine hydrolase
Identifiers
EC no.	3.3.1.2
CAS no.	37288-62-3
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are S-adenosyl-L-methionine and H₂O, whereas its two products are L-homoserine and methylthioadenosine.

This enzyme belongs to the family of hydrolases, specifically those acting on ether bonds involving sulfur (thioether and trialkylsulfonium hydrolases). The systematic name of this enzyme class is S-adenosyl-L-methionine hydrolase. Other names in common use include S-adenosylmethionine cleaving enzyme, methylmethionine-sulfonium-salt hydrolase, and adenosylmethionine lyase.