A-86929

A-86929 is a synthetic compound that acts as a selective dopamine receptor D₁ agonist.^[1][2] It was developed as a possible treatment for Parkinson's disease,^[3] as well as for other applications such as treatment of cocaine addiction,^[4][5] but while it had reasonable efficacy in humans it also caused dyskinesias and has not been continued.^[6][7] It has mainly been used as its diacetate ester prodrug adrogolide (ABT-431), which has better bioavailability.^[8][9]

Adrogolide

A-86929

Names
Preferred IUPAC name (5aR,11bS)-2-Propyl-4,5,5a,6,7,11b-hexahydrobenzo[f]thieno[2,3-c]quinoline-9,10-diol
Identifiers
CAS Number	166591-11-3 Y
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL28338 Y
ChemSpider	8017113 Y
PubChem CID	9841398
UNII	69MG3OZA0H Y
CompTox Dashboard (EPA)	DTXSID501028589 DTXSID50938440, DTXSID501028589
InChI InChI=1S/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m1/s1 Y Key: REHAKLRYABHSQJ-KDOFPFPSSA-N Y InChI=1/C18H21NO2S/c1-2-3-11-7-13-17(22-11)9-19-14-5-4-10-6-15(20)16(21)8-12(10)18(13)14/h6-8,14,18-21H,2-5,9H2,1H3/t14-,18+/m1/s1 Key: REHAKLRYABHSQJ-KDOFPFPSBO
SMILES Oc1cc3c(cc1O)CCC4C3c2cc(CCC)sc2CN4
Properties
Chemical formula	C18H21NO2S
Molar mass	315.429 g/mol
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references