Aerobactin synthase

In enzymology, an aerobactin synthase (EC 6.3.2.39) is an enzyme that catalyzes the chemical reaction

4 ATP + citrate + 2 N⁶-acetyl-N⁶-hydroxy-L-lysine + 2 H₂O ${\displaystyle \rightleftharpoons }$ 4 ADP + 4 phosphate + aerobactin

aerobactin synthase
Identifiers
EC no.	6.3.2.39
CAS no.	94047-30-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 4 substrates of this enzyme are ATP, citrate, N6-acetyl-N6-hydroxy-L-lysine, and H₂O, whereas its 3 products are ADP, phosphate, and aerobactin.

This enzyme belongs to the family of ligases, specifically those forming carbon-nitrogen bonds as acid-D-amino-acid ligases (peptide synthases). The systematic name of this enzyme class is citrate:N⁶-acetyl-N⁶-hydroxy-L-lysine ligase (ADP-forming). This enzyme is also called citrate:6-N-acetyl-6-N-hydroxy-L-lysine ligase (ADP-forming). This enzyme participates in lysine degradation.