Alpha-glucuronidase

For beta-glucuronidase, see Beta-glucuronidase

alpha-glucuronidase
Identifiers
EC no.	3.2.1.139
CAS no.	37259-81-7
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

In enzymology, an alpha-glucuronidase (EC 3.2.1.139) is an enzyme that catalyzes the chemical reaction

an alpha-D-glucuronoside + H₂O ${\displaystyle \rightleftharpoons }$ an alcohol + D-glucuronate

Thus, the two substrates of this enzyme are alpha-D-glucuronoside and H₂O, whereas its two products are alcohol and D-glucuronate.

This enzyme belongs to the family of hydrolases, to be specific those glycosidases that hydrolyse O- and S-glycosyl compounds. The systematic name of this enzyme class is alpha-D-glucosiduronate glucuronohydrolase. This enzyme is also called alpha-glucosiduronase.

Structural studies

As of late 2007, 13 structures have been solved for this class of enzymes, with PDB accession codes 1GQI, 1GQJ, 1GQK, 1GQL, 1H41, 1K9D, 1K9E, 1K9F, 1L8N, 1MQP, 1MQQ, 1MQR, and 1VJT.

See also

• Beta-glucuronidase
• Glucuronosyl-disulfoglucosamine glucuronidase
• Glycyrrhizinate beta-glucuronidase