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Argininosuccinic acid

Chemical compound From Wikipedia, the free encyclopedia

Argininosuccinic acid
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Argininosuccinic acid is a non-proteinogenic amino acid that is an important intermediate in the urea cycle. [1] It is also known as argininosuccinate.[2]

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Some cells synthesize argininosuccinic acid from citrulline and aspartic acid and use it as a precursor for arginine in the urea cycle (or citrulline-NO cycle), releasing fumarate as a by-product to enter the TCA cycle. The enzyme that catalyzes the reaction is argininosuccinate synthetase.[3][4]

Argininosuccinic acid is a precursor to fumarate in the citric acid cycle via argininosuccinate lyase.[5]

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