Arogenate dehydrogenase (NAD(P)+)

In enzymology, an arogenate dehydrogenase [NAD(P)+] (EC 1.3.1.79) is an enzyme that catalyzes the chemical reaction

L-arogenate + NAD(P)+ ${\displaystyle \rightleftharpoons }$ L-tyrosine + NAD(P)H + CO₂

Arogenate dehydrogenase (NAD(P)+)
Identifiers
EC no.	1.3.1.79
CAS no.	64295-75-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are L-arogenate, NAD⁺, and NADP⁺, whereas its 4 products are L-tyrosine, NADH, NADPH, and CO₂.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is L-arogenate:NAD(P)+ oxidoreductase (decarboxylating). Other names in common use include arogenic dehydrogenase (ambiguous), cyclohexadienyl dehydrogenase, and pretyrosine dehydrogenase (ambiguous).