Arsenate reductase (glutaredoxin)

Arsenate reductase (glutaredoxin) (EC 1.20.4.1) is an enzyme that catalyzes the chemical reaction

arsenate + glutaredoxin ${\displaystyle \rightleftharpoons }$ arsenite + glutaredoxin disulfide + H₂O

arsenate reductase (glutaredoxin)
Identifiers
EC no.	1.20.4.1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are arsenate and glutaredoxin, whereas its 3 products are arsenite, glutaredoxin disulfide, and water.

This enzyme belongs to the family of oxidoreductases, specifically those acting on phosphorus or arsenic in donor with disulfide as acceptor. The systematic name of this enzyme class is glutaredoxin:arsenate oxidoreductase.

Structural studies

As of late 2007, 12 structures have been solved for this class of enzymes, with PDB accession codes 1RXE, 1RXI, 1S3C, 1S3D, 1SD8, 1SD9, 1SJZ, 1SK0, 1SK1, 1SK2, 1Z2D, and 1Z2E.