Aryl-aldehyde dehydrogenase (NADP+)

In enzymology, an aryl-aldehyde dehydrogenase (NADP+) (EC 1.2.1.30) is an enzyme that catalyzes the chemical reaction

an aromatic aldehyde + NADP⁺ + AMP + diphosphate + H₂O ${\displaystyle \rightleftharpoons }$ an aromatic acid + NADPH + H⁺ + ATP

aryl-aldehyde dehydrogenase (NADP+)
Identifiers
EC no.	1.2.1.30
CAS no.	9074-94-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 5 substrates of this enzyme are aromatic aldehyde, NADP⁺, AMP, diphosphate, and H₂O, whereas its 4 products are aromatic acid, NADPH, H⁺, and ATP.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is aryl-aldehyde:NADP+ oxidoreductase (ATP-forming). Other names in common use include aromatic acid reductase, and aryl-aldehyde dehydrogenase (NADP+).