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B3 domain
DNA binding domain From Wikipedia, the free encyclopedia
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The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors (≥40 species) (Pfam PF02362) combined with other domains (InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold (SCOP 117343); it interacts with the major groove of DNA.[1]
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B3 families
In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain:[2]
- ARF (Auxin Response Factors)
- ABI3 (ABscisic acid Insensitive3)
- RAV (Related to ABI3/VP1)
PDB: 1WID[1] and PDB: 1YEL[8] are only known NMR solution phase structures of the B3 DNA Binding Domain.
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Related proteins
The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold.[9][10]
See also
- Restriction endonuclease EcoRII
- Auxin
- Abscisic acid
References
External links
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