B3 domain

DNA binding domain From Wikipedia, the free encyclopedia

B3 domain

The B3 DNA binding domain (DBD) is a highly conserved domain found exclusively in transcription factors (≥40 species) (Pfam PF02362) combined with other domains (InterPro: IPR003340). It consists of 100-120 residues, includes seven beta strands and two alpha helices that form a DNA-binding pseudobarrel protein fold (SCOP 117343); it interacts with the major groove of DNA.[1]

Quick Facts Identifiers, Symbol ...
B3 DNA binding domain
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B3 DNA binding domain of RAV1
Identifiers
SymbolB3_domain
PfamPF02362
InterProIPR003340
PROSITEPS50863
SCOP21wid / SCOPe / SUPFAM
CDDcd10017
Available protein structures:
Pfam  structures / ECOD  
PDBRCSB PDB; PDBe; PDBj
PDBsumstructure summary
PDB1wid, 1yel
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B3 families

In Arabidopsis thaliana, there are three main families of transcription factors that contain B3 domain:[2]

More information protein, ARF1- ...
protein ARF1-B3 ABI3-B3 RAV1-B3
B3 structure derived by molecular model[1] molecular model[1] NMR[1]
B3 recognition sequence TGTCTC[3][4] CATGCA[5][6] CACCTG[7]
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PDB: 1WID[1] and PDB: 1YEL[8] are only known NMR solution phase structures of the B3 DNA Binding Domain.

The N-terminal domain of restriction endonuclease EcoRII; the C-terminal domain of restriction endonuclease BfiI possess a similar DNA-binding pseudobarrel protein fold.[9][10]

See also

References

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