BAG1

BAG family molecular chaperone regulator 1 is a protein that in humans is encoded by the BAG1 gene.^[5]

BAG1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 1HX1, 1WXV, 3FZF, 3FZH, 3FZK, 3FZL, 3FZM, 3LDQ, 3M3Z
Identifiers
Aliases	BAG1, BAG-1, HAP, RAP46, BCL2 associated athanogene 1, BAG cochaperone 1
External IDs	OMIM: 601497; MGI: 108047; HomoloGene: 3190; GeneCards: BAG1; OMA:BAG1 - orthologs
Gene location (Human) Chr. Chromosome 9 (human)[1] Band 9p13.3 Start 33,247,820 bp[1] End 33,264,720 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 A5 Start 40,936,398 bp[2] End 40,948,294 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in palpebral conjunctiva sperm apex of heart olfactory zone of nasal mucosa right auricle of heart right testis left testis skin of abdomen gastrocnemius muscle skin of leg Top expressed in seminiferous tubule epithelium of stomach lacrimal gland crypt of lieberkuhn of small intestine blood mucous cell of stomach decidua right kidney muscle of thigh parotid gland More reference expression data BioGPS More reference expression data
Gene ontology Molecular function chaperone binding protein binding adenyl-nucleotide exchange factor activity ubiquitin protein ligase binding Cellular component cytoplasm cytosol nucleus Biological process regulation of cellular response to heat cell surface receptor signaling pathway negative regulation of apoptotic process apoptotic process regulation of catalytic activity chaperone cofactor-dependent protein refolding Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 573 12017 Ensembl ENSG00000107262 ENSMUSG00000028416 UniProt Q99933 Q60739 RefSeq (mRNA) NM_004323 NM_001172415 NM_001349286 NM_001349299 NM_001171739 NM_009736 RefSeq (protein) NP_001165886 NP_004314 NP_001336215 NP_001336228 NP_001165210 NP_033866 Location (UCSC) Chr 9: 33.25 – 33.26 Mb Chr 4: 40.94 – 40.95 Mb PubMed search [3] [4]
Wikidata
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Function

The oncogene BCL2 is a membrane protein that blocks a step in a pathway leading to apoptosis or programmed cell death. The protein encoded by this gene binds to BCL2 and is referred to as BCL2-associated athanogene. It enhances the anti-apoptotic effects of BCL2 and represents a link between growth factor receptors and anti-apoptotic mechanisms. At least three protein isoforms are encoded by this mRNA through the use of alternative translation initiation sites, including a non-AUG site.^[6]

Clinical significance

BAG gene has been implicated in age related neurodegenerative diseases as Alzheimer's. It has been demonstrated that BAG1 and BAG 3 regulate the proteasomal and lysosomal protein elimination pathways, respectively.^[7]

Interactions

BAG1 has been shown to interact with:

• Androgen receptor,^[8][9][10]
• C-Raf,^[11]
• Calcitriol receptor,^[12]
• Glucocorticoid receptor,^[13][14]
• HSPA8,^[15][16]
• HBEGF,^[17]
• PPP1R15A,^[18]
• NR1B1,^[19] and
• SIAH1.^[20]