Beta-ketoacyl-ACP synthase I

This article is about the specific variant of the enzyme type I. For the function and the enzyme in general, see Beta-ketoacyl-ACP synthase.

In enzymology, a beta-ketoacyl-acyl-carrier-protein synthase I (EC 2.3.1.41) is an enzyme that catalyzes the chemical reaction

an acyl-acyl-carrier-protein + malonyl-acyl-carrier-protein ${\displaystyle \rightleftharpoons }$ a 3-oxoacyl-acyl-carrier-protein + CO₂ + acyl-carrier-protein

3-oxoacyl-[acyl-carrier-protein] synthase I
Identifiers
EC no.	2.3.1.41
CAS no.	9077-10-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are acyl-acyl-carrier-protein and malonyl-acyl-carrier-protein, whereas its 3 products are 3-oxoacyl-acyl-carrier-protein, CO₂, and acyl carrier protein. This enzyme participates in fatty acid biosynthesis. This enzyme belongs to the family of transferases, specifically those acyltransferases transferring groups other than aminoacyl groups.

Nomenclature

The systematic name of this enzyme class is acyl-[acyl-carrier-protein]:malonyl-[acyl-carrier-protein] C-acyltransferase (decarboxylating).

Other names in common use include:

• beta-ketoacyl-ACP synthase I,
• beta-ketoacyl synthetase,
• beta-ketoacyl-ACP synthetase,
• beta-ketoacyl-acyl carrier protein synthetase,
• beta-ketoacyl-[acyl carrier protein] synthase,
• beta-ketoacylsynthase,
• condensing enzyme (CE),
• 3-ketoacyl-acyl carrier protein synthase,
• fatty acid condensing enzyme,
• acyl-malonyl(acyl-carrier-protein)-condensing enzyme,
• acyl-malonyl acyl carrier protein-condensing enzyme,
• beta-ketoacyl acyl carrier protein synthase,
• 3-oxoacyl-[acyl-carrier-protein] synthase,
• 3-oxoacyl:ACP synthase I,
• KASI,
• KAS I,
• FabF1, and
• FabB.