Ethacridine lactate

Ethacridine lactate (ethacridine monolactate monohydrate, acrinol, trade name Rivanol) is an aromatic organic compound based on acridine. Its formal name is 2-ethoxy-6,9-diaminoacridine monolactate monohydrate. It forms orange-yellow crystals with a melting point of 226 °C and it has a stinging smell.

Ethacridine lactate

Clinical data
AHFS/Drugs.com	International Drug Names
ATC code	B05CA08 (WHO) D08AA01 (WHO)
Identifiers
IUPAC name 7-Ethoxyacridine-3,9-diamine 2-hydroxypropanoic acid
CAS Number	1837-57-6 N
PubChem CID	15789
ChemSpider	15012 Y
UNII	7T7T2I9823
KEGG	D01248 Y
ChEMBL	ChEMBL582355 Y
CompTox Dashboard (EPA)	DTXSID10872472
ECHA InfoCard	100.015.826
Chemical and physical data
Formula	C18H21N3O4
Molar mass	343.383 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)C(O)C.O(c2ccc1nc3c(c(c1c2)N)ccc(c3)N)CC
InChI InChI=1S/C15H15N3O.C3H6O3/c1-2-19-10-4-6-13-12(8-10)15(17)11-5-3-9(16)7-14(11)18-13;1-2(4)3(5)6/h3-8H,2,16H2,1H3,(H2,17,18);2,4H,1H3,(H,5,6) Y Key:IYLLULUTZPKQBW-UHFFFAOYSA-N Y
NY (what is this?)  (verify)

Its primary use is as an antiseptic^[1] in solutions of 0.1%. It is effective against mostly Gram-positive bacteria, such as Streptococci and Staphylococci, but ineffective against Gram-negative bacteria such as Pseudomonas aeruginosa.^[2]

Ethacridine is also used as an agent for second trimester abortion. Up to 150 ml of a 0.1% solution is instilled extra-amniotically using a foley catheter. After 20 to 40 hours, 'mini labor' ensues. In China, an intra-amniotic method has also been used.^[3] Ethacridine as an abortifacient is found to be safer and better tolerated than 20% hypertonic saline.