Α3IA

α3IA, also known as GTPL4094, is an inverse agonist of the GABA_A receptor. It is more selective for the α3 subunit, hence its name.

α3IA^[1]

Names
IUPAC name Methyl 5-(4-methoxyphenyl)-1-methyl-2-oxo-6-pyridin-4-ylpyridine-3-carboxylate
Identifiers
3D model (JSmol)	Interactive image
ChEMBL	ChEMBL413325
ChemSpider	9998940
IUPHAR/BPS	4094
PubChem CID	11824289
InChI InChI=1S/C20H18N2O4/c1-22-18(14-8-10-21-11-9-14)16(12-17(19(22)23)20(24)26-3)13-4-6-15(25-2)7-5-13/h4-12H,1-3H3 Key: LENMNEQXCQXJHV-UHFFFAOYSA-N
SMILES CN1C(=C(C=C(C1=O)C(=O)OC)C2=CC=C(C=C2)OC)C3=CC=NC=C3
Properties
Chemical formula	C20H18N2O4
Molar mass	350.374 g·mol−1
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). Infobox references

Effects

Agonism of the α3 subunit shows anxiolytic properties. However, by being an inverse agonist, α3IA has the opposite action: it shows anxiogenic properties.^[2]

This compound also has affinity for the other subunits of the GABA_A receptor, but it is more selective for the α3 subunit.^[3]

See also

• α5IA, an inverse agonist at the α5 subunit of GABA_A receptors