Glabridin

Glabridin is a chemical compound that is found in the root extract of licorice (Glycyrrhiza glabra).^[2] Glabridin is an isoflavane, a type of isoflavonoid. This product is part of a larger family of plant-derived molecules, the natural phenols. Glabridin effectively inhibits platelet activation, so it might become therapeutic agent for thromboembolic disorders.^[3]

Glabridin

Names
IUPAC name (3R)-6′′,6′′-Dimethyl-6′′H-pyrano[2′′,3′′:7,8]isoflavan-2′,4′-diol
Systematic IUPAC name 4-[(3R)-8,8-Dimethyl-3,4-dihydro-2H,8H-(benzo[1,2-b:3,4-b′]dipyran)-3-yl]benzene-1,3-diol
Identifiers
CAS Number	59870-68-7 Y
3D model (JSmol)	Interactive image
ChEBI	CHEBI:5369 N
ChEMBL	ChEMBL480477 Y
ChemSpider	110560 Y
ECHA InfoCard	100.126.141
PubChem CID	124052
UNII	HOC5567T41 Y
CompTox Dashboard (EPA)	DTXSID00208589
InChI InChI=1S/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 Y Key: LBQIJVLKGVZRIW-ZDUSSCGKSA-N Y InChI=1/C20H20O4/c1-20(2)8-7-16-18(24-20)6-3-12-9-13(11-23-19(12)16)15-5-4-14(21)10-17(15)22/h3-8,10,13,21-22H,9,11H2,1-2H3/t13-/m0/s1 Key: LBQIJVLKGVZRIW-ZDUSSCGKBA
SMILES O4c2c1\C=C/C(Oc1ccc2C[C@H](c3ccc(O)cc3O)C4)(C)C
Properties
Chemical formula	C20H20O4
Molar mass	324.376 g·mol−1
Appearance	Yellowish-brown powder
Melting point	238–240 °C (460–464 °F; 511–513 K)[1]
Except where otherwise noted, data are given for materials in their standard state (at 25 °C [77 °F], 100 kPa). N verify (what is YN ?) Infobox references

It is used as an ingredient in cosmetics and is listed in International Nomenclature of Cosmetic Ingredients (INCI).

Glabridin is yellowish-brown powder. It is insoluble in water, but soluble in organic solvents such as propylene glycol.

See also

• Glabrene
• Isoliquiritigenin
• Liquiritigenin