Progesterone dioxime

Progesterone dioxime
Clinical data
Other names	Progesterone 3,20-dioxime; P4-3,20-DO; Pregn-4-ene-3,20-dione 3,20-dioxime; 3,20-Di(hydroxyimino)pregn-4-en-3-one
Identifiers
	IUPAC name (NZ)-N-[1-[(3E,8S,9S,10R,13S,14S,17S)-3-hydroxyimino-10,13-dimethyl-1,2,6,7,8,9,11,12,14,15,16,17-dodecahydrocyclopenta[a]phenanthren-17-yl]ethylidene]hydroxylamine;
CAS Number	26144-38-7;
PubChem CID	91692079;
ChemSpider	7875670;
UNII	PYB4REL6XV;
Chemical and physical data
Formula	C21H32N2O2
Molar mass	344.499 g·mol−1
3D model (JSmol)	Interactive image;
Melting point	238–242 °C (460–468 °F) (recrystallized from alcohol)
	SMILES C/C(=N/O)/[C@H]1CC[C@@H]2[C@@]1(CC[C@H]3[C@H]2CCC4=C/C(=N/O)/CC[C@]34C)C;
	InChI InChI=1S/C21H32N2O2/c1-13(22-24)17-6-7-18-16-5-4-14-12-15(23-25)8-10-20(14,2)19(16)9-11-21(17,18)3/h12,16-19,24-25H,4-11H2,1-3H3/b22-13-,23-15+/t16-,17+,18-,19-,20-,21+/m0/s1; Key:JKENIRSEIALBGX-GWUBATFGSA-N;

Progesterone dioxime, or progesterone 3,20-dioxime (P4-3,20-DO), also known as 3,20-di(hydroxyimino)pregn-4-en-3-one, is a progesterone derivative which was never marketed.^[1] It is a progestogen oxime – specifically, the C3 and C20 dioxime of the progestogen progesterone.^[1] Progesterone C3 and C20 oxime conjugates have been found to be water-soluble prodrugs of progesterone and pregnane neurosteroids.^[2]^[3]^[4]^[5]

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See also