Artelinic acid

Artelinic acid (or its salt, artelinate) is an experimental drug that is being investigated as a treatment for malaria.^[1] It is a semi-synthetic derivative of the natural compound artemisinin. Artelinic acid has a lower rate of neurotoxicity than the related artemisinin derivatives arteether and artemether,^[2] but is three times more toxic than artesunate.^[3] At present,^[when?] artelinic acid seems unlikely to enter routine clinical use, because it offers no clear benefits over the artemesinins already available (artesunate and artemether). Artelinic acid has not yet been evaluated for use in humans.^[when?]

Artelinic acid

Clinical data
ATC code	none
Identifiers
IUPAC name 4-[(3R,5aS,6R,8aS,9R,10S,12R,12aR)-decahydro- 3,6,9-trimethyl-3,12-epoxy-12H-pyrano[4,3-j]-1,2- benzodioxepin-10-yl]oxy]methylbenzoic acid
CAS Number	120020-26-0 Y
PubChem CID	180423 beta-Artelinic acid: 10341948
ChemSpider	8517407 N
UNII	08X93406PG
ChEMBL	ChEMBL477080 N
CompTox Dashboard (EPA)	DTXSID501316558
Chemical and physical data
Formula	C23H30O7
Molar mass	418.486 g·mol−1
3D model (JSmol)	Interactive image
SMILES O=C(O)c1ccc(cc1)CO[C@H]4O[C@@H]5O[C@@]3(OO[C@]52[C@@H](CC[C@@H](C)[C@@H]2CC3)[C@H]4C)C
InChI InChI=1S/C23H30O7/c1-13-4-9-18-14(2)20(26-12-15-5-7-16(8-6-15)19(24)25)27-21-23(18)17(13)10-11-22(3,28-21)29-30-23/h5-8,13-14,17-18,20-21H,4,9-12H2,1-3H3,(H,24,25)/t13-,14-,17+,18+,20+,21-,22-,23-/m1/s1 N Key:UVNHKOOJXSALHN-ILQPJIFQSA-N N
NY (what is this?)  (verify)