Milameline

Milameline (CI-979, PD-129,409, RU-35,926) is a non-selective muscarinic acetylcholine receptor partial agonist with cognition-acting properties that was being investigated for the treatment of Alzheimer's disease, but produced poor results in clinical trials and was subsequently discontinued.^[1]

• Changing the O-methyl aldoxime to an O-propargyl oxime instead gives a separate molecule called RU 35986.^[2]

Milameline

Clinical data
ATC code	None
Identifiers
IUPAC name (E)-N-methoxy-1-(1-methyl-1,2,5,6-tetrahydropyridin-3-yl)methanimine
CAS Number	139886-32-1
PubChem CID	9571002
IUPHAR/BPS	301
ChemSpider	7845468
UNII	R9X77R42FN
CompTox Dashboard (EPA)	DTXSID401028867
ECHA InfoCard	100.220.595
Chemical and physical data
Formula	C8H14N2O
Molar mass	154.213 g·mol−1
3D model (JSmol)	Interactive image
SMILES N(/OC)=C\C1=C\CCN(C)C1

See also

• Alvameline
• Sabcomeline
• Tazomeline
• Xanomeline