CBLC

Signal transduction protein CBL-C is a protein that in humans is encoded by the CBLC gene.^[5][6][7]

CBLC
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 3OP0, 3VRN, 3VRO, 3VRP, 3VRQ, 3VRR
Identifiers
Aliases	CBLC, CBL-3, CBL-SL, RNF57, Cbl proto-oncogene C
External IDs	OMIM: 608453; MGI: 1931457; HomoloGene: 8108; GeneCards: CBLC; OMA:CBLC - orthologs
Gene location (Human) Chr. Chromosome 19 (human)[1] Band 19q13.32 Start 44,777,869 bp[1] End 44,800,652 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 A3 Start 19,512,806 bp[2] End 19,530,734 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in mucosa of transverse colon skin of abdomen skin of leg duodenum right lobe of liver body of pancreas jejunal mucosa rectum olfactory zone of nasal mucosa minor salivary glands Top expressed in duodenum intestinal villus right kidney epithelium of stomach jejunum lip proximal tubule colon esophagus lumbar spinal ganglion More reference expression data BioGPS More reference expression data
Gene ontology Molecular function SH3 domain binding phosphotyrosine residue binding calcium ion binding epidermal growth factor receptor binding ubiquitin protein ligase activity metal ion binding ubiquitin-protein transferase activity transferase activity receptor tyrosine kinase binding zinc ion binding protein binding Cellular component plasma membrane membrane raft Biological process negative regulation of epidermal growth factor-activated receptor activity cell surface receptor signaling pathway negative regulation of epidermal growth factor receptor signaling pathway negative regulation of MAP kinase activity protein ubiquitination regulation of signaling ubiquitin-dependent protein catabolic process signal transduction Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 23624 80794 Ensembl ENSG00000142273 ENSMUSG00000040525 UniProt Q9ULV8 Q80XL1 RefSeq (mRNA) NM_001130852 NM_012116 NM_001161844 NM_023224 RefSeq (protein) NP_001124324 NP_036248 NP_001155316 NP_075713 Location (UCSC) Chr 19: 44.78 – 44.8 Mb Chr 7: 19.51 – 19.53 Mb PubMed search [3] [4]
Wikidata
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CBL proteins, such as CBLC, are phosphorylated upon activation of a variety of receptors that signal via protein tyrosine kinases. Through interactions with proteins containing SRC (MIM 190090) homology-2 (SH2) and SH3 domains, CBL proteins modulate downstream cell signaling (Keane et al., 1999).[supplied by OMIM]^[7]

Interactions

CBLC has been shown to interact with FYN^[8] and Epidermal growth factor receptor.^[6][9]