CDP-glucose 4,6-dehydratase

The enzyme CDP-glucose 4,6-dehydratase (EC 4.2.1.45) catalyzes the chemical reaction

CDP-glucose ${\displaystyle \rightleftharpoons }$ CDP-4-dehydro-6-deoxy-D-glucose + H₂O

CDP-glucose 4,6-dehydratase
Identifiers
EC no.	4.2.1.45
CAS no.	37259-55-5
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. This enzyme participates in starch and sucrose metabolism. It employs one cofactor, NAD⁺.

Nomenclature

The systematic name of this enzyme class is CDP-glucose 4,6-hydro-lyase (CDP-4-dehydro-6-deoxy-D-glucose-forming). Other names in common use include:

• cytidine diphosphoglucose oxidoreductase, and
• CDP-glucose 4,6-hydro-lyase.

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1RKX and 1WVG.