CENTD2

Arf-GAP with Rho-GAP domain, ANK repeat and PH domain-containing protein 1 is a protein that in humans is encoded by the ARAP1 gene.^[5]

ARAP1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 4X1V
Identifiers
Aliases	ARAP1, CENTD2, ArfGAP with RhoGAP domain, ankyrin repeat and PH domain 1, cnt-d2
External IDs	OMIM: 606646; MGI: 1916960; HomoloGene: 12326; GeneCards: ARAP1; OMA:ARAP1 - orthologs
Gene location (Human) Chr. Chromosome 11 (human)[1] Band 11q13.4 Start 72,685,069 bp[1] End 72,793,599 bp[1]
Gene location (Mouse) Chr. Chromosome 7 (mouse)[2] Band 7|7 E2 Start 100,997,274 bp[2] End 101,061,793 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in granulocyte monocyte right uterine tube upper lobe of left lung right lung spleen right adrenal cortex left adrenal cortex anterior pituitary right lobe of thyroid gland Top expressed in granulocyte lip gastrula stroma of bone marrow efferent ductule tibiofemoral joint thymus lumbar spinal ganglion uterus spleen More reference expression data BioGPS n/a
Gene ontology Molecular function metal ion binding protein binding GTPase activator activity phosphatidylinositol-3,4,5-trisphosphate binding type 1 angiotensin receptor binding Cellular component cytoplasm Golgi apparatus membrane Golgi cisterna membrane trans-Golgi network cytoplasmic vesicle nucleoplasm cytosol plasma membrane intracellular membrane-bounded organelle Biological process actin filament reorganization involved in cell cycle regulation of cell shape negative regulation of stress fiber assembly regulation of small GTPase mediated signal transduction positive regulation of filopodium assembly signal transduction positive regulation of receptor recycling positive regulation of epidermal growth factor receptor signaling pathway positive regulation of GTPase activity Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 116985 69710 Ensembl ENSG00000186635 ENSMUSG00000032812 UniProt Q96P48 Q4LDD4 RefSeq (mRNA) NM_015242 NM_001040118 NM_001135190 NM_001369489 NM_001040111 NM_001040112 NM_027180 NM_198096 RefSeq (protein) NP_001035207 NP_001128662 NP_056057 NP_001356418 NP_001035200 NP_001035201 NP_081456 NP_932764 NP_001394730 NP_001394732 Location (UCSC) Chr 11: 72.69 – 72.79 Mb Chr 7: 101 – 101.06 Mb PubMed search [3] [4]
Wikidata
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Function

The protein encoded by this gene contains ARF-GAP, RHO-GAP, ankyrin repeat, RAS-associating, and pleckstrin homology domains. In vitro, this protein displays RHO-GAP and phosphatidylinositol (3,4,5) trisphosphate (PIP3)-dependent ARF-GAP activity. The encoded protein associates with the Golgi, and the ARF-GAP activity mediates changes in the Golgi and the formation of filopodia. The RHO-GAP activity may mediate cell rounding and loss of stress fibers. At least three transcript variants encoding different isoforms have been found for this gene, but the full-length natures of all variants have not been determined.^[5]