CLIC4

Chloride intracellular channel 4, also known as CLIC4,p644H1,HuH1, is a eukaryotic gene.^[5]

CLIC4
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2AHE, 2D2Z, 3OQS
Identifiers
Aliases	CLIC4, CLIC4L, H1, MTCLIC, huH1, p64H1, chloride intracellular channel 4
External IDs	OMIM: 606536; MGI: 1352754; HomoloGene: 8490; GeneCards: CLIC4; OMA:CLIC4 - orthologs
Gene location (Human) Chr. Chromosome 1 (human)[1] Band 1p36.11 Start 24,745,382 bp[1] End 24,844,321 bp[1]
Gene location (Mouse) Chr. Chromosome 4 (mouse)[2] Band 4|4 D3 Start 134,941,280 bp[2] End 135,000,125 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in saphenous vein tail of epididymis popliteal artery tibial arteries vena cava Descending thoracic aorta smooth muscle tissue ascending aorta right coronary artery urethra Top expressed in gastrula right lung right lung lobe decidua ascending aorta cardiac muscle tissue of left ventricle sciatic nerve semi-lunar valve left lung atrioventricular valve More reference expression data BioGPS More reference expression data
Gene ontology Molecular function voltage-gated ion channel activity protein binding glutathione transferase activity chloride channel activity Cellular component cytoplasm integral component of membrane cytosol centrosome membrane cell-cell junction nuclear matrix microtubule cytoskeleton plasma membrane apical part of cell intracellular anatomical structure chloride channel complex microtubule organizing center microvillus cell surface cell junction midbody mitochondrion actin cytoskeleton perinuclear region of cytoplasm extracellular exosome cytoskeleton cytoplasmic vesicle membrane cytoplasmic vesicle nucleus Biological process cellular response to calcium ion cell differentiation multicellular organism growth regulation of ion transmembrane transport endothelial cell morphogenesis ion transport keratinocyte differentiation vacuolar acidification negative regulation of cell migration fertilization establishment or maintenance of apical/basal cell polarity chloride transport branching morphogenesis of an epithelial tube retina vasculature morphogenesis in camera-type eye regulation of cytoskeleton organization angiogenesis glutathione metabolic process chloride transmembrane transport transport ion transmembrane transport Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 25932 29876 Ensembl ENSG00000169504 ENSMUSG00000037242 UniProt Q9Y696 Q9QYB1 RefSeq (mRNA) NM_013943 NM_013885 RefSeq (protein) NP_039234 NP_038913 Location (UCSC) Chr 1: 24.75 – 24.84 Mb Chr 4: 134.94 – 135 Mb PubMed search [3] [4]
Wikidata
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Chloride channels are a diverse group of proteins that regulate fundamental cellular processes including stabilization of cell membrane potential, transepithelial transport, maintenance of intracellular pH, and regulation of cell volume. Chloride intracellular channel 4 (CLIC4) protein, encoded by the clic4 gene, is a member of the p64 family; the gene is expressed in many tissues. These channels are implicated in angiogenesis, pulmonary hypertension, cancer, and cardioprotection from ischemia-reperfusion injury. They exhibit an intracellular vesicular pattern in PANC-1 cells (pancreatic cancer cells).^[5]

Binding partners

CLIC4 binds to dynamin I, α-tubulin, β-actin, creatine kinase and two 14-3-3 isoforms.^[6]

See also

• Chloride channel