CP-94253

CP-94253 is a drug of the tetrahydropyridinylpyrrolopyridine family which acts as a potent and selective serotonin 5-HT_1B receptor agonist, with approximately 25× and 40× selectivity over the closely related 5-HT_1D and 5-HT_1A receptors.^[1]

CP-94253

Clinical data
Other names	CP94253; CP-94,253
Identifiers
IUPAC name 3-(1,2,5,6-tetrahydro-4-pyridyl)-5-propoxypyrrolo[3,2-b]pyridine
CAS Number	131084-35-0 Y
PubChem CID	4029677
IUPHAR/BPS	3221
ChemSpider	3246572 N
UNII	FYC6YY5RYL
CompTox Dashboard (EPA)	DTXSID10470073
Chemical and physical data
Formula	C15H19N3O
Molar mass	257.337 g·mol−1
3D model (JSmol)	Interactive image
SMILES c13nc(OCCC)ccc1[nH]cc3C2=CCNCC2
InChI InChI=1S/C15H19N3O/c1-2-9-19-14-4-3-13-15(18-14)12(10-17-13)11-5-7-16-8-6-11/h3-5,10,16-17H,2,6-9H2,1H3 N Key:KWQWBZIGHIOKIO-UHFFFAOYSA-N N
NY (what is this?)  (verify)

It has a range of behavioral effects, based on animal testing. The effects include the following: promoting wakefulness by increasing dopamine release in the brain;^[2][3] reducing food intake and promoting satiety;^[4][5][6] enhancing the reinforcing effects of cocaine;^{[7][8][9][10]} and possible antidepressant effects.^[11]

A 2021 study^[12] found that "Regardless of sex, CP94253 decreased cocaine intake after abstinence and during resumption of SA [self-administration] and decreased cue reactivity" suggesting that agonism of the inhibitory 5-HT2B receptors may diminish the cognitive reward of cocaine usage and increased use of the drug without a period of abstinence may be a product of test subjects trying to achieve a previously rewarding experience through larger dosages of cocaine.

See also

• Tetrahydropyridinylpyrrolopyridine