CREB1

CAMP responsive element binding protein 1, also known as CREB-1, is a protein that in humans is encoded by the CREB1 gene.^[5][6] This protein binds the cAMP response element, a DNA nucleotide sequence present in many viral and cellular promoters. The binding of CREB1 stimulates transcription.

CREB1
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LXT
Identifiers
Aliases	CREB1, CREB, CREB-1, cAMP responsive element binding protein 1
External IDs	OMIM: 123810; MGI: 88494; HomoloGene: 3223; GeneCards: CREB1; OMA:CREB1 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q33.3 Start 207,529,737 bp[1] End 207,605,988 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1 C2|1 32.74 cM Start 64,571,804 bp[2] End 64,643,707 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in secondary oocyte Achilles tendon bone marrow cell superficial temporal artery trabecular bone left testis ganglionic eminence skin of hip right testis epithelium of nasopharynx Top expressed in medial ganglionic eminence Rostral migratory stream ciliary body genital tubercle retinal pigment epithelium pineal gland human fetus conjunctival fornix maxillary prominence tail of embryo More reference expression data BioGPS More reference expression data
Gene ontology Molecular function DNA-binding transcription factor activity DNA-binding transcription activator activity, RNA polymerase II-specific cAMP response element binding transcription coregulator activity RNA polymerase II cis-regulatory region sequence-specific DNA binding enzyme binding protein binding double-stranded DNA binding DNA binding sequence-specific DNA binding identical protein binding transcription factor activity, RNA polymerase II distal enhancer sequence-specific binding DNA-binding transcription factor activity, RNA polymerase II-specific transcription factor binding Hsp70 protein binding histone acetyltransferase binding arrestin family protein binding Cellular component mitochondrion nucleus ATF4-CREB1 transcription factor complex chromatin transcription regulator complex nucleoplasm axon mitochondrial matrix Biological process cellular response to nerve growth factor stimulus positive regulation of lipid biosynthetic process positive regulation of long-term synaptic potentiation rhythmic process cellular response to insulin-like growth factor stimulus transcription by RNA polymerase II response to organic substance mammary gland development protein phosphorylation type I pneumocyte differentiation circadian rhythm positive regulation of multicellular organism growth response to L-glutamate lung saccule development lung epithelium development transforming growth factor beta receptor signaling pathway regulation of apoptotic process cellular response to transforming growth factor beta stimulus response to glucagon regulation of transcription, DNA-templated negative regulation of transcription by competitive promoter binding response to nicotine positive regulation of osteoclast differentiation memory negative regulation of gene expression transcription, DNA-templated positive regulation of transcription, DNA-templated lactation positive regulation of transforming growth factor beta3 production viral process positive regulation of fat cell differentiation negative regulation of neuron death cell differentiation cellular response to hepatocyte growth factor stimulus protein stabilization cellular response to platelet-derived growth factor stimulus regulation of circadian rhythm secretory granule organization regulation of glial cell proliferation visual learning regulation of cell size pituitary gland development positive regulation of RNA polymerase II transcription preinitiation complex assembly response to hypoxia axonogenesis regulation of fibroblast proliferation cellular response to growth factor stimulus ageing chemotaxis to arachidonic acid response to activity cellular response to zinc ion cellular response to fatty acid positive regulation of apoptotic process positive regulation of hormone secretion signal transduction positive regulation of transcription by RNA polymerase II positive regulation of cardiac muscle tissue development cellular response to leukemia inhibitory factor cellular response to retinoic acid Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 1385 12912 Ensembl ENSG00000118260 ENSMUSG00000025958 UniProt P16220 Q01147 RefSeq (mRNA) NM_004379 NM_134442 NM_001320793 NM_001371426 NM_001371427 NM_001371428 NM_001037726 NM_009952 NM_133828 RefSeq (protein) NP_001307722 NP_004370 NP_604391 NP_001358355 NP_001358356 NP_001358357 NP_001032815 NP_034082 NP_598589 Location (UCSC) Chr 2: 207.53 – 207.61 Mb Chr 1: 64.57 – 64.64 Mb PubMed search [3] [4]
Wikidata
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This protein is a CREB transcription factor that is a member of the leucine zipper family of DNA-binding proteins. This protein binds as a homodimer to the cAMP-responsive element, an octameric palindrome. The protein is phosphorylated by several protein kinases, and induces transcription of genes in response to hormonal stimulation of the cAMP pathway. Alternate splicing of this gene results in two transcript variants encoding different isoforms.^[7]

See also

• CREB

Interactions

CREB1 has been shown to interact with:

• CEBPB,^[8]
• CREB binding protein,^{[9][10][11][12][13][14][15][16][17][18]}
• FHL2,^[19]
• FHL3,^[19]
• FHL5.^[19]
• HTATIP,^[20]
• P53,^[15] and
• RPS6KA5.^[21][22]