Calphostin

The calphostins are a class of closely related chemical compounds isolated from the fungus Cladosporium cladosporioides.^[1][2] The known calphostins include calphostin A, calphostin B, calphostin C, calphostin D, and calphostin I. The calphostins are inhibitors of protein kinase C (PKC).^[1][2] The most potent member of the series, calphostin C,^[1] has found use as a biochemical tool because of this activity.^[3]

Calpohostin	R1	R2
Calphostin A	Bz	Bz
Calphostin B	Bz	H
Calphostin C	Bz	4-(HO)Bz
Calphostin D	H	H
Calphostin I	4-(HO)Bz	4-(HO)Bz

Calphostin C

Main article: Calphostin C

Calphostin C is a potent inhibitor of protein kinase C (PKC).^[1][2][3]