Carboxylate reductase

In enzymology, a carboxylate reductase (EC 1.2.99.6) is an enzyme that catalyzes the chemical reaction

an aldehyde + acceptor + H₂O ${\displaystyle \rightleftharpoons }$ a carboxylate + reduced acceptor

carboxylate reductase
Identifiers
EC no.	1.2.99.6
CAS no.	125008-36-8
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are aldehyde, acceptor, and H₂O, whereas its two products are carboxylate and reduced acceptor.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with other acceptors. The systematic name of this enzyme class is aldehyde:acceptor oxidoreductase. This enzyme is also called aldehyde:(acceptor) oxidoreductase. This enzyme participates in pyruvate metabolism. It employs one cofactor, tungsten.