One Health Trust

One Health Trust, formerly the Center for Disease Dynamics, Economics & Policy, is a public health research organization with offices in Washington, D.C., New Delhi, and Bangalore, India.^[1]

One Health Trust

Formation	2009 (2009)
Headquarters	5636 Connecticut Avenue NW, PO Box 42735, Washington, D.C. 20015, U.S.A.
Location	Washington, D.C.
Founder & President	Ramanan Laxminarayan
Website	onehealthtrust.org

Established in 2010, the organization announced its transition to becoming the One Health Trust in 2022^[2] to reflect an expanded research focus. This shift broadened the organization's scope of to include One Health topics, such as animal health, planetary health, and climate change.^[3]

Overview

The One Health Trust employs a multidisciplinary team comprising economists, epidemiologists, social scientists, microbiologists, veterinarians, medical doctors, and disease modelers. The organization conducts research across a range of public health areas, including antimicrobial resistance, zoonotic and vector borne diseases, environmental health, social determinants of health, vaccines and immunization, and other topics related to the One Health approach.^[4]

Primary activities

WHO Collaborating Center for Antimicrobial Resistance

The One Health Trust has been a World Health Organization Collaborating Center for antimicrobial resistance since 2020. The One Health Trust's researchers support the WHO in several activities to address the global health crisis of antimicrobial resistance.^[5][6]

One Health Trust has published country-specific policy and information briefs reviewing progress in implementing national action plans on antimicrobial resistance as a World Health Organization Collaborating Center.^[7]

Antimicrobial Resistance Research in Africa

As part of the Mapping Antimicrobial Resistance and Antimicrobial Use Partnership consortium,^[8] One Health Trust conducted data surveillance and analysis in Africa to determine the extent of antimicrobial resistance in the continent. The consortium included the African Society for Laboratory Medicine, Africa Centers for Disease Control and Prevention,^{[9][circular reference]} West African Health Organization, East Central & Southern Africa Health Community, IQVIA,^{[clarification needed]} and Innovative Support to Emergencies, Diseases and Disasters.

The project was funded by the Fleming Fund^[10] and involved data collection on antimicrobial resistance from public and private laboratories and pharmacies throughout Africa. The Mapping Antimicrobial Resistance and Antimicrobial Use Partnership consortium reviewed 819,584 antimicrobial resistance records from 2016-2019 from 205 laboratories across the 14 African Union Member States — Burkina Faso, Cameroon, Eswatini, Gabon, Ghana, Kenya, Malawi, Nigeria, Senegal, Sierra Leone, Tanzania, Uganda, Zambia, and Zimbabwe.^[11]

The OxygenForIndia Initiative

The OxygenForIndia initiative was launched by One Health Trust and partnering institutions to address critical medical oxygen shortages in India.^[12]

In April 2021, during a medical oxygen supply crisis,^[13][14] OxygenForIndia deployed 20,000 reusable oxygen cylinders and 3,000 oxygen concentrators in 57 urban and rural centers across India. Currently, the One Health Trust team and partners are working to build a stable and reliable oxygen supply system^[15] to avoid preventable deaths and improve pandemic preparedness. To achieve this objective, researchers are evaluating fiscal initiatives and building India's health system capacities.^[16]

Global Antibiotic Resistance Partnership

The One Health Trust is a technical partner in the Global Antibiotic Resistance Partnership, which was initiated in 2008 to help low- and middle-income countries develop country-led strategies and policies to address antimicrobial resistance.^{[17][18][19][20]}

Modeling Infectious Diseases in Healthcare Network (MInD – Healthcare)

One Health Trust is a member of the U.S. Centers for Disease Control and Prevention's MInD – Healthcare Network, which supports transmission modeling research to get insights on the drivers of healthcare-associated infections and antibiotic-resistant infections and estimate the benefits of preventive measures.^[21]

Affordable Medicines Facility - Malaria

The Affordable Medicines Facility — Malaria grew from a 2004 Institute of Medicines (IOM) report co-authored by One Health Trust's Dr. Ramanan Laxminarayan.^{[22][circular reference][23]} The project addressed the issue of rising antimalarial drug resistance against the most commonly used malaria treatment at the time, chloroquine, by finding ways to get artemisinin-based combination therapies — the most effective malaria treatments known — into private pharmacies and village shops.^[24][25]

Through negotiating bulk orders and subsidies, the Affordable Medicines Facility - Malaria team worked to leverage the extensive existing private-sector infrastructure in Africa to get good medicines where there were none before, lowering prices of effective antimalarials in rural Africa.^[26] The scheme, which ran from 2010 through 2012, was tested in seven African countries and was found successful in increasing the number of outlets stocking artemisinin-based combination therapies and lowering prices.^[27]

PhD program in Data Sciences for Global Health in partnership with Birla Institute of Technology & Science, Pilani

The One Health Trust, in partnership with Birla Institute of Technology & Science (BITS) in Pilani, India, has a PhD program in Data Sciences for Global Health to provide training in global health issues and research methodology with fieldwork and data analysis.^[28] This program is full-time.^[29]

ResistanceMap

The One Health Trust's ResistanceMap is a collection of tools summarizing national and subnational data on antimicrobial use and resistance globally.^[30] Since its launch in 2010, ResistanceMap has been used to inform researchers, policy makers, and the public of important trends in drug resistance and antibiotic use.^[31][32]

In 2015, ResistanceMap was updated with a new design interface, expanded tools, and the addition of antibiotic use and resistance data from several low- and middle-income countries in Africa, Asia and South America.^[33]

One World, One Health Podcast

The One World, One Health podcast^[34] by the One Health Trust was launched in 2022. The podcast is interview-style and the host, Maggie Fox, talks to scientific researchers about topics including pandemics, antimicrobial resistance, the impact of deforestation on human health, among other related issues.