Channel-conductance-controlling ATPase

In enzymology, a channel-conductance-controlling ATPase (EC 3.6.3.49) is an enzyme that catalyzes the chemical reaction

ATP + H₂O ${\displaystyle \rightleftharpoons }$ ADP + phosphate

channel-conductance-controlling ATPase
Identifiers
EC no.	3.6.3.49
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are ATP and H₂O, whereas its two products are ADP and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on acid anhydrides to catalyse transmembrane movement of substances. The systematic name of this enzyme class is ATP phosphohydrolase (channel-conductance-controlling).

Structural studies

As of late 2007, two structures have been solved for this class of enzymes, with PDB accession codes 1XMI and 1XMJ.