Citrate—CoA ligase

In enzymology, a citrate—CoA ligase (EC 6.2.1.18) is an enzyme that catalyzes the chemical reaction

ATP + citrate + CoA ${\displaystyle \rightleftharpoons }$ ADP + phosphate + (3S)-citryl-CoA

Citrate—CoA ligase
Identifiers
EC no.	6.2.1.18
CAS no.	856428-87-0
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, citrate, and CoA, whereas its 3 products are ADP, phosphate, and (3S)-citryl-CoA.

This enzyme belongs to the family of ligases, specifically those forming carbon-sulfur bonds as acid-thiol ligases. The systematic name of this enzyme class is citrate:CoA ligase (ADP-forming). Other names in common use include citryl-CoA synthetase, citrate:CoA ligase, and citrate thiokinase. This enzyme participates in citric acid cycle.