Citrullinase

In enzymology, a citrullinase (EC 3.5.1.20) is an enzyme that catalyzes the chemical reaction

L-citrulline + H₂O ${\displaystyle \rightleftharpoons }$ L-ornithine + CO₂ + NH₃

citrullinase
Identifiers
EC no.	3.5.1.20
CAS no.	59088-17-4
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are L-citrulline and H₂O, whereas its 3 products are L-ornithine, CO₂, and NH₃.

This enzyme belongs to the family of hydrolases, those acting on carbon-nitrogen bonds other than peptide bonds, specifically in linear amides. The systematic name of this enzyme class is L-citrulline N5-carbamoyldihydrolase. Other names in common use include citrulline ureidase, citrulline hydrolase, and L-citrulline 5-N-carbamoyldihydrolase.