Codeinone reductase (NADPH)

In enzymology, a codeinone reductase (NADPH) (EC 1.1.1.247) is an enzyme that catalyzes the chemical reaction

codeine + NADP⁺ ${\displaystyle \rightleftharpoons }$ codeinone + NADPH + H⁺

codeinone reductase (NADPH)
Identifiers
EC no.	1.1.1.247
CAS no.	153302-41-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are codeine and NADP⁺, whereas its 3 products are codeinone, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is codeine:NADP⁺ oxidoreductase. This enzyme participates in alkaloid biosynthesis i.