Ctgf/hcs24 CAESAR

ctgf/hcs24 CAESAR is the name given to the cis-acting RNA element identified in the 3' untranslated region (3'UTR) of the human connective tissue growth factor (CTGF) messenger RNA.^[1] This gene is also known as hypertrophic chondrocyte specific 24 (hcs24).

ctgf/hcs24 CAESAR
Predicted secondary structure and sequence conservation of CAESAR
Identifiers
Symbol	CAESAR
Rfam	RF00172
Other data
RNA type	Cis-reg
Domain(s)	Eukaryota
SO	SO:0000233
PDB structures	PDBe

The importance of the 3'UTR in repressing ctgf gene expression was initially characacterised^[1] and subsequently the minimal RNA element responsible for repression was identified^[2] This element was predicted to form a stable secondary structure, which acts as a post-transcriptional cis-acting element of structure-anchored repression (CAESAR).

The 3'UTR of the ctgf/hcs24 gene in chicken has also been shown to be involved in repression of gene expression.^[3]