Cycloartenol synthase

In enzymology, a cycloartenol synthase (EC 5.4.99.8) is an enzyme that catalyzes the chemical reaction

(S)-2,3-epoxysqualene ${\displaystyle \rightleftharpoons }$ cycloartenol

cycloartenol synthase
Identifiers
EC no.	5.4.99.8
CAS no.	9075-25-6
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Hence, this enzyme has one substrate, (S)-2,3-epoxysqualene, and one product, cycloartenol.

This enzyme is an oxidosqualene cyclase and belongs to the family of isomerases, specifically those intramolecular transferases transferring other groups. This enzyme participates in biosynthesis of steroids.

Nomenclature

The systematic name of this enzyme class is:

• (S)-2,3-epoxysqualene mutase (cyclizing, cycloartenol-forming).

Other names in common use include:

• 2,3-epoxysqualene cycloartenol-cyclase
• squalene-2,3-epoxide-cycloartenol cyclase
• 2,3-epoxysqualene cycloartenol-cyclase
• 2,3-epoxysqualene-cycloartenol cyclase
• 2,3-oxidosqualene-cycloartenol cyclase