Delta24-sterol reductase

In enzymology, a Delta24-sterol reductase (EC 1.3.1.72) is an enzyme that catalyzes the chemical reaction.

5alpha-cholest-7-en-3beta-ol + NADP⁺ ${\displaystyle \rightleftharpoons }$ 5alpha-cholesta-7,24-dien-3beta-ol + NADPH + H⁺

delta24-sterol reductase
Identifiers
EC no.	1.3.1.72
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are 5alpha-cholest-7-en-3beta-ol and NADP⁺, whereas its 3 products are 5alpha-cholesta-7,24-dien-3beta-ol, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-CH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is sterol:NADP+ Delta24-oxidoreductase. This enzyme is also called lanosterol Delta24-reductase, and it participates in biosynthesis of steroids.