DBX2

Homeobox protein DBX2, also known as developing brain homeobox protein 2, is a protein that in humans is encoded by the DBX2 gene.^[5][6] DBX2, a homeodomain-containing protein, plays an important role in the development of the central nervous system, specifically in the development of the neural tube and brain.^[7] The gene DBX2 is located on chromosome 12 and is approximately 36,000 base pairs long. DBX2 is predicted to enable DNA-binding transcription activity as well as being involved in the regulation of transcription by RNA polymerase II.^[8]

DBX2
Identifiers
Aliases	DBX2, developing brain homeobox 2
External IDs	MGI: 107445; HomoloGene: 54981; GeneCards: DBX2; OMA:DBX2 - orthologs
Gene location (Human) Chr. Chromosome 12 (human)[1] Band 12q12 Start 45,014,672 bp[1] End 45,051,099 bp[1]
Gene location (Mouse) Chr. Chromosome 15 (mouse)[2] Band 15 E3|15 50.47 cM Start 95,521,444 bp[2] End 95,553,841 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in testicle gonad substantia nigra Hypothalamus C1 segment Amygdala anterior cingulate cortex prefrontal cortex putamen hippocampus proper Top expressed in dentate gyrus of hippocampal formation granule cell lumbar subsegment of spinal cord phalanx of foot hallux visual cortex embryo phalanx of big toe primary visual cortex phalanx of second toe embryo More reference expression data BioGPS n/a
Gene ontology Molecular function sequence-specific DNA binding DNA binding DNA-binding transcription factor activity, RNA polymerase II-specific Cellular component nucleus Biological process regulation of transcription, DNA-templated regulation of transcription by RNA polymerase II Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 440097 223843 Ensembl ENSG00000185610 ENSMUSG00000045608 UniProt Q6ZNG2 n/a RefSeq (mRNA) NM_001004329 NM_207533 RefSeq (protein) NP_001004329 n/a Location (UCSC) Chr 12: 45.01 – 45.05 Mb Chr 15: 95.52 – 95.55 Mb PubMed search [3] [4]
Wikidata
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Identification

Dbx (developing brain homeobox) was first isolated from a gestational day 13.5 mouse in 1992.^[9] There are two Dbx genes (DBX1 and DBX2) which are both important for development of the central nervous system. DBX2 shows conserved expression patterns in the developing brain and spinal cord and plays an important role in neural patterning and differentiation.

Associated diseases

DBX2 has been found to play an important role in the development of glioblastoma which is a lethal brain cancer with poor prognosis.^[10] A high expression of DBX2 has been linked to large tumor size in hepatocellular carcinoma^[11] while downregulated expression of DBX2 has been associated with endometrial cancer.^[12]