DNA/RNA non-specific endonuclease

In molecular biology, enzymes in the DNA/RNA non-specific endonuclease family of bacterial and eukaryotic endonucleases EC 3.1.30.- share the following characteristics: they act on both DNA and RNA, cleave double-stranded and single-stranded nucleic acids and require a divalent ion such as magnesium for their activity. A histidine has been shown to be essential for the activity of the Serratia marcescens nuclease. This residue is located in a conserved region which also contains an aspartic acid residue that could be implicated in the binding of the divalent ion.^[1]

Endonuclease_NS
identification of the serratia endonuclease dimer: structural basis and implications for catalysis
Identifiers
Symbol	Endonuclease_NS
Pfam	PF01223
Pfam clan	CL0263
InterPro	IPR001604
PROSITE	PDOC00821
SCOP2	1smn / SCOPe / SUPFAM
CDD	cd00091
Available protein structures: Pfam   structures / ECOD   PDB RCSB PDB; PDBe; PDBj PDBsum structure summary

Notable members of the family include Serratia marcescens NucA and human Exonuclease G.