DNAJB2

DnaJ homolog subfamily B member 2 is a protein that in humans is encoded by the DNAJB2 gene.^[5][6][7]

DNAJB2
Available structures PDB Ortholog search: PDBe RCSB List of PDB id codes 2LGW
Identifiers
Aliases	DNAJB2, DSMA5, HSJ-1, HSJ1, HSPF3, CMT2T, DnaJ heat shock protein family (Hsp40) member B2
External IDs	OMIM: 604139; MGI: 1928739; HomoloGene: 4902; GeneCards: DNAJB2; OMA:DNAJB2 - orthologs
Gene location (Human) Chr. Chromosome 2 (human)[1] Band 2q35 Start 219,279,342 bp[1] End 219,286,898 bp[1]
Gene location (Mouse) Chr. Chromosome 1 (mouse)[2] Band 1|1 C4 Start 75,236,406 bp[2] End 75,245,692 bp[2]
RNA expression pattern Bgee Human Mouse (ortholog) Top expressed in C1 segment right hemisphere of cerebellum right frontal lobe anterior pituitary amygdala cingulate gyrus anterior cingulate cortex prefrontal cortex Brodmann area 9 tibial nerve Top expressed in motor neuron lens spermatid neural layer of retina supraoptic nucleus retinal pigment epithelium spermatocyte muscle of thigh aortic valve blood More reference expression data BioGPS More reference expression data
Gene ontology Molecular function polyubiquitin modification-dependent protein binding proteasome binding chaperone binding protein binding ubiquitin protein ligase binding ATPase activator activity Hsp70 protein binding unfolded protein binding ubiquitin binding ubiquitin-dependent protein binding Cellular component inclusion body proteasome complex cytosol nucleus cytoplasm endoplasmic reticulum endoplasmic reticulum membrane membrane intrinsic component of endoplasmic reticulum membrane nuclear membrane Biological process response to unfolded protein negative regulation of protein deubiquitination positive regulation of protein ubiquitination positive regulation of proteasomal ubiquitin-dependent protein catabolic process ubiquitin-dependent ERAD pathway protein refolding negative regulation of inclusion body assembly regulation of protein localization regulation of protein ubiquitination negative regulation of protein binding positive regulation of ATP-dependent activity proteasome-mediated ubiquitin-dependent protein catabolic process chaperone-mediated protein folding regulation of chaperone-mediated protein folding negative regulation of cell population proliferation negative regulation of cell growth neuron cellular homeostasis Sources:Amigo / QuickGO
Orthologs Species Human Mouse Entrez 3300 56812 Ensembl ENSG00000135924 ENSMUSG00000026203 UniProt P25686 Q9QYI5 RefSeq (mRNA) NM_006736 NM_001039550 NM_001159883 NM_001159884 NM_001159885 NM_020266 NM_178055 RefSeq (protein) NP_001034639 NP_006727 NP_001153355 NP_001153356 NP_001153357 NP_064662 NP_835156 Location (UCSC) Chr 2: 219.28 – 219.29 Mb Chr 1: 75.24 – 75.25 Mb PubMed search [3] [4]
Wikidata
View/Edit Human View/Edit Mouse