TRNA (cytosine38-C5)-methyltransferase

TRNA (cytosine38-C5)-methyltransferase (EC 2.1.1.204, hDNMT2 (gene), DNMT2 (gene), TRDMT1 (gene)) is an enzyme with the systematic name S-adenosyl-L-methionine:tRNA (cytosine38-C5)-methyltransferase.^[1][2][3] This enzyme catalyses the following chemical reaction:

S-adenosyl-L-methionine + cytosine³⁸ in tRNA ${\displaystyle \rightleftharpoons }$ S-adenosyl-L-homocysteine + 5-methylcytosine³⁸ in tRNA

TRNA (cytosine38-C5)-methyltransferase
Identifiers
EC no.	2.1.1.204
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Search PMC articles PubMed articles NCBI proteins

The eukaryotic enzyme catalyses methylation of cytosine³⁸ in the anti-codon loop of tRNAAsp(GTC), tRNAVal(AAC) and tRNAGly(GCC).

See also

• TRDMT1