DTDP-4-dehydro-6-deoxyglucose reductase

In enzymology, a dTDP-4-dehydro-6-deoxyglucose reductase (EC 1.1.1.266) is an enzyme that catalyzes the chemical reaction

dTDP-D-fucose + NADP⁺ ${\displaystyle \rightleftharpoons }$ dTDP-4-dehydro-6-deoxy-D-glucose + NADPH + H⁺

dTDP-4-dehydro-6-deoxyglucose reductase
Identifiers
EC no.	1.1.1.266
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

Thus, the two substrates of this enzyme are dTDP-D-fucose and NADP⁺, whereas its 3 products are dTDP-4-dehydro-6-deoxy-D-glucose, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is dTDP-D-fucose:NADP⁺ oxidoreductase. This enzyme is also called dTDP-4-keto-6-deoxyglucose reductase. This enzyme participates in polyketide sugar unit biosynthesis.