Demecarium bromide

Not to be confused with Decamethonium.

Demecarium bromide, trade name Humorsol, is a carbamate parasympathomimetic drug that acts as an acetylcholinesterase inhibitor, and is used as a glaucoma medication. It is applied directly to the eye in order to reduce elevated intraocular pressure associated with glaucoma.^[1]

Demecarium bromide

Clinical data
Trade names	Humorsol
Routes of administration	Topical (ophthalmic solution)
ATC code	S01EB04 (WHO)
Identifiers
IUPAC name Trimethyl-[3-[methyl-[10-[methyl-(3-trimethylammoniophenoxy)carbonyl-amino]decyl]carbamoyl]oxyphenyl]ammonium dibromide
CAS Number	56-94-0 Y
PubChem CID	5965
DrugBank	DB00944 Y
ChemSpider	5750 Y
UNII	61D5V4OKTP
KEGG	D00667 Y
ChEBI	CHEBI:4391 Y
ChEMBL	ChEMBL1200514 N
CompTox Dashboard (EPA)	DTXSID6045240
ECHA InfoCard	100.000.274
Chemical and physical data
Formula	C32H52Br2N4O4
Molar mass	716.600 g·mol−1
3D model (JSmol)	Interactive image
SMILES [Br-].[Br-].O=C(Oc1cccc(c1)[N+](C)(C)C)N(CCCCCCCCCCN(C(=O)Oc2cccc(c2)[N+](C)(C)C)C)C
InChI InChI=1S/C32H52N4O4.2BrH/c1-33(31(37)39-29-21-17-19-27(25-29)35(3,4)5)23-15-13-11-9-10-12-14-16-24-34(2)32(38)40-30-22-18-20-28(26-30)36(6,7)8;;/h17-22,25-26H,9-16,23-24H2,1-8H3;2*1H/q+2;;/p-2 Y Key:YHKBUDZECQDYBR-UHFFFAOYSA-L Y
NY (what is this?)  (verify)

Demecarium causes constriction of the pupil (miosis), which improves the drainage of the fluid in the eye (aqueous humour).^[2] As demecarium reversibly inhibits cholinesterase, it can be administered less frequently than other parasympathomimetic drugs, such as carbachol.^[3]

Commercially produced demecarium bromide solution, previously sold under the trade name Humorsol,^[4] is no longer available,^[3] although solutions of demecarium can be compounded.^[5]

Use in dogs

When administered with a topical corticosteroid, demecarium can delay the onset of primary glaucoma in dogs.^[3] High doses of demecarium may cause organophosphate toxicity, particularly if flea treatments containing organophosphates are administered at the same time.^[3]

See also

• Diisopropyl fluorophosphate