Dethiobiotin synthase

In enzymology, a dethiobiotin synthase (EC 6.3.3.3) is an enzyme that catalyzes the chemical reaction

ATP + 7,8-diaminononanoate + CO₂ ${\displaystyle \rightleftharpoons }$ ADP + phosphate + dethiobiotin

Dethiobiotin synthase
Identifiers
EC no.	6.3.3.3
CAS no.	37259-75-9
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are ATP, 7,8-diaminononanoate, and CO₂, whereas its 3 products are ADP, phosphate, and dethiobiotin.

This enzyme belongs to the family of ligases, specifically the cyclo-ligases, which form carbon-nitrogen bonds. The systematic name of this enzyme class is 7,8-diaminononanoate:carbon-dioxide cyclo-ligase (ADP-forming). This enzyme is also called desthiobiotin synthase. This enzyme participates in biotin metabolism.

Structural studies

As of late 2007, 14 structures have been solved for this class of enzymes, with PDB accession codes 1A82, 1BS1, 1BYI, 1DAD, 1DAE, 1DAF, 1DAG, 1DAH, 1DAI, 1DAK, 1DAM, 1DBS, 1DTS, and 2QMO.