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Mengla dianlovirus
Species of virus From Wikipedia, the free encyclopedia
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Mengla dianlovirus (MLAV, also written Měnglà virus) is a type of filovirus identified in a Rousettus bat in Mengla County, Yunnan Province, China, and was first reported in January 2019.[1] It is classified in the same family as Ebolavirus and Marburgvirus.[2]
It is the only member of the genus Dianlovirus.[1] The name derives from 滇 (diān), the Chinese language abbreviation for Yunnan, added to "filovirus", the common name for Filoviridae.[1] Neither the species nor the genus are listed in the 2018 ICTV classification, as the virus was formally described after that report was released.[3] A formal proposal was submitted for the taxa in January 2019.[4]
MLAV proteins, including VP35 and VP40, inhibit host immune responses by interfering with interferon signaling, contributing to immune evasion similar to other filoviruses.[5] Like other filoviruses, Mengla virus utilizes the Niemann-Pick C1 (NPC1) receptor for cell entry, a trait that may facilitate cross-species transmission.[6]
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