Diferric-transferrin reductase

In enzymology, a diferric-transferrin reductase (EC 1.16.1.2) is an enzyme that catalyzes the chemical reaction

transferrin[Fe(II)]2 + NAD⁺ + H⁺ ${\displaystyle \rightleftharpoons }$ transferrin[Fe(III)]2 + NADH

diferric-transferrin reductase
Identifiers
EC no.	1.16.1.2
CAS no.	105238-49-1
Databases
IntEnz	IntEnz view
BRENDA	BRENDA entry
ExPASy	NiceZyme view
KEGG	KEGG entry
MetaCyc	metabolic pathway
PRIAM	profile
PDB structures	RCSB PDB PDBe PDBsum
Gene Ontology	AmiGO / QuickGO
Search PMC articles PubMed articles NCBI proteins

The 3 substrates of this enzyme are [[transferrin[Fe(II)]2]], NAD⁺, and H⁺, whereas its two products are [[transferrin[Fe(III)]2]] and NADH.

This enzyme belongs to the family of oxidoreductases, specifically those oxidizing metal ion with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is transferrin[Fe(II)]2:NAD+ oxidoreductase. Other names in common use include diferric transferrin reductase, NADH diferric transferrin reductase, and transferrin reductase. This enzyme participates in porphyrin and chlorophyll metabolism.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1L5T.