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Dihydroxy-acid dehydratase

From Wikipedia, the free encyclopedia

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The enzyme dihydroxy-acid dehydratase (EC 4.2.1.9) catalyzes the chemical reaction

2,3-dihydroxy-3-methylbutanoate 3-methyl-2-oxobutanoate + H2O

This enzyme participates in valine, leucine and isoleucine biosynthesis and pantothenate and coenzyme A (CoA) biosynthesis.

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Nomenclature

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is 2,3-dihydroxy-3-methylbutanoate hydro-lyase (3-methyl-2-oxobutanoate-forming). Other names in common use include

  • acetohydroxyacid dehydratase,
  • α,β-dihydroxyacid dehydratase,
  • 2,3-dihydroxyisovalerate dehydratase,
  • α,β-dihydroxyisovalerate dehydratase,
  • dihydroxy acid dehydrase,
  • DHAD,
  • and 2,3-dihydroxy-acid hydro-lyase.
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References

Further reading

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